MORRIS F. MADURO
Assistant Professor of Biology
(Associate Professor as of July '08)
Office 3380E Spieth Hall
Phone (951) 827-7196
E-mail: mmaduro@citrus.ucr.edu
Degree:
Ph.D., University of Alberta, 1998
Dr. Maduro studies the developmental mechanisms of cell fate specification in the nematode, C. elegans. Specifically, he is interested in the regulatory gene network that specifies the embryonic mesoderm (MS) and endoderm (E) precursor cells. The regulators MED-1 and MED-2 function together with the evolutionarily conserved Wnt pathway to specify these cells. Current work involves understanding the molecular basis for Wnt/MED-1,2 activity and elaborating the mesoderm gene network. The C. elegans system features a rich repertoire of tools for gene analysis, such as a complete genome sequence, transgenesis, functional genomics, and reverse genetics.
Dr. Maduro participates in the Cell, Molecular, and Developmental Biology and Genetics, Genomics and Bioinformatics graduate programs, and is a cooperating faculty member with the Department of Nematology.
Some Representative Publications....
- Gay, F., Calvo, D., Lo, M-C., Ceron, J., Maduro, M., Lin, R. L., and Shi, Y. (2003) Acetylation regulates subcellular localization of the Wnt signaling nuclear effector POP-1. Genes Dev 17: 717-722. Abstract
- Maduro MF, Lin R, and Rothman JH (2002) Dynamics of a developmental switch: recursive intracellular and intranuclear redistribution of C. elegans POP-1 parallels Wnt-inhibited transcriptional repression. Dev Biol 248: 128-142. Abstract
- Maduro MF, and Rothman JH (2002) Making Worm Guts: The Gene Regulatory Network of the C. elegans Endoderm. Dev Biol 246(1):68-85. Abstract
- Calvo D, Victor M, Gay, F., Sui G, Luke MP-S, Dufourcq P, Wen G, Maduro M, Rothman JH, and Shi Y (2001) A POP-1 repressor complex restricts inappropriate cell type-specific gene transcription during C. elegans embryogenesis. EMBO J. 20(24): 7197-7208. Abstract
- Maduro MF, Meneghini MD, Bowerman B, Broitman-Maduro G, Rothman JH (2001) Restriction of mesendoderm to a single blastomere by the combined action of SKN-1 and a GSK-3ß homolog is mediated by MED-1 and -2 in C. elegans. Molecular Cell 7(3): 475-485. (Cover Article) Abstract
- Maduro MF, Gordon M, Jacobs R, Pilgrim DB (2000) The UNC-119 family of neural proteins is functionally conserved between humans, Drosophila and C. elegans. J Neurogenet 13(4): 191-212. Abstract
- Maduro MF, Pilgrim DB (1995) Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics 141(3): 977-88. Abstract
Recent Teaching....
- Biology 168, Developmental Biology
- Biology 005A, Introduction to Cell and Molecular Biology (co-taught with 1 professor)
- CMDB 202, Graduate Course in Developmental Biology (co-taught with 2 professors)
- CMDB 257, Graduate Seminar (co-organizer)