Professor of Biology
Office 2318 Spieth Hall
Phone (951) 827-4322
Ph.D., Yale University, 1996
Spider silks are among the most diverse and interesting of animal structural proteins. The large variety of silk types results from a multitude of uses, both within and between species. In addition to the huge diversity of spider taxa (they are one of the most species-rich of major animal groups), each individual produces as many as six or seven distinct varieties of silk from a battery of specialized glands. The different silks serve different purposes, ranging from web construction and prey capture to courtship and nest-building. The mechanical properties of silk -- elasticity, tensile properties, breaking strength, etc. -- are ultimately dependent on the sequence of amino acids that form silk proteins. Dr. Hayashi is interested in spider silks across many levels of biological integration, from the molecular genetics and evolution of the various silk genes to analyses of the protein sequences of different types of silk to biomechanical testing of the functional properties of the final product. Because of the unusually tight linkage between silk gene DNA sequences and functional ecology, these studies have easily understood connections to ecological, behavioral, and evolutionary questions.
Dr. Hayashi participates in the Evolutionary Biology and Physiology tracks within the EEOB Graduate Program, as well as the Cell, Molecular, and Developmental Biology and Genetics, Genomics, and Bioinformatics Graduate Programs. In addition, she participates in the Evolutionary Biology Joint-Doctoral Program with San Diego State University.
Some Representative Publications ...
- Hayashi, C. and R. Lewis. 2000. Molecular architecture and the evolution of a modular spider silk protein gene. Science. 287:1477-1479.
- Hayashi, C., N. Shipley, and R. Lewis. 1999. Hypotheses that correlate the sequence, structure, and mechanical properties of spider silks. International Journal of Biological Macromolecules. 24:271-275.
- Wheeler, W. and C. Hayashi. 1998. The phylogeny of extant chelicerate orders. Cladistics. 14:173-192.
- Hayashi, C. and R. Lewis. 1998. Evidence from flagelliform silk cDNA for the structural basis of elasticity and modular nature of spider silks. Journal of Molecular Biology. 275:773-784.
- Gatesy, J., C. Hayashi, M. Cronin, and P. Arctander. 1996. Evidence from milk casein genes that cetaceans are close relatives of hippopotamid artiodactyls. Molecular Biology and Evolution. 13:954-963.
- Gatesy, J., C. Hayashi, R. DeSalle, and E. Vrba. 1994. Rate limits for mispairing and compensatory change: the mitochondrial ribosomal DNA of antelopes. Evolution 48:188-196.
- Wheeler, W., P. Cartwright, and C. Hayashi. 1993. Arthropod phylogeny: a combined approach. Cladistics 9:1-39.